Innate Immunity in the Lower Female Mucosal Tract
نویسندگان
چکیده
منابع مشابه
Mucosal Immunity in the Female Genital Tract, HIV/AIDS
Mucosal immunity consists of innate and adaptive immune responses which can be influenced by systemic immunity. Despite having been the subject of intensive studies, it is not fully elucidated what exactly occurs after HIV contact with the female genital tract mucosa. The sexual route is the main route of HIV transmission, with an increased risk of infection in women compared to men. Several ch...
متن کاملThe UDP-glucose receptor P2RY14 triggers innate mucosal immunity in the female reproductive tract by inducing IL-8.
Innate mucosal immune responses, including recognition of pathogen-associated molecular patterns through Toll-like receptors, play an important role in preventing infection in the female reproductive tract (FRT). Damaged cells release nucleotides, including ATP and uridine 5'-diphosphoglucose (UDP-glucose), during inflammation and mechanical stress. We show in this report that P2RY14, a membran...
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Fatal cases of acute shock complicating Clostridium sordellii endometritis following medical abortion with mifepristone (also known as RU-486) used with misoprostol were reported. The pathogenesis of this unexpected complication remains enigmatic. Misoprostol is a pharmacomimetic of PGE(2), an endogenous suppressor of innate immunity. Clinical C. sordellii infections were associated with intrav...
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A large mucosal immune system controlled by unique, organ-specific regulations operates alongside and separate from the peripheral or systemic immune system. This local immune system is seen as a major interface between the innate and the specific immune system. We have been interested in the immunopathogenesis of a chronic inflammatory bowel disease (IBD) developing in CD4+ T cell-transplanted...
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Mucosal epithelial tissues are exposed to high numbers of microbes, including commensal fungi, and are able to distinguish between those that are avirulent and those that cause disease. Epithelial cells have evolved multiple mechanisms to defend against colonization and invasion by Candida species. The interplay between mucosal epithelial tissues and immune cells is key for control and clearanc...
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ژورنال
عنوان ژورنال: Journal of Steroids & Hormonal Science
سال: 2011
ISSN: 2157-7536
DOI: 10.4172/2157-7536.1000106